Glucokinase has a lower affinity to glucose than hexokinase, and also, glucokinase is present mainly in the liver. I don't know the difference in their molecular structures, though.

Dr. Fatemeh Kourkinejad

almost 7 years ago

Hexokinase catalyze Glc and Fru. Glucokinase catalyze Glc only.

Dr.Mohd Muneer

almost 7 years ago

Glucokinase has high Km value for glucose than hexokinase and is mainly present in liver unlike hexokinase

José Gutiérrez

almost 7 years ago

Hexokinase has a higher affinity to glucose whereas glucokinase has a lower one. This means Gk has a higher value of Km than the other. This means Gk works when glucose blood concentration is high. Gk acts like a sensor. It 'sensorize' wether glucose blood concentration is high. This is the reason why this enzyme is located in liver and pancreas.