In the attached video you can find learning material regarding the mechanism of action, medical uses, drug interactions, side effects and toxicity management of methotrexate. Timeline: 0:00 - Mechanism of action of methotrexate 3:46 - Pharmacological uses, dosage and route of administration 4:26 - Interaction with trimethoprim 4:49 - Side effects, usage contraindicatios, toxicity and toxicity management