Both mebendazole and albendazole have similar mechanisms of action when it comes to their anti-helminthic actions. However, there are certain key differences between the two drugs in terms of their killing spectra, dosage, and side effects. Watch this video and find more about the distinguishing features which make one drug preferable over the other in certain situations. Timeline: 0.05- Differences between albendazole and mebendazole 4.00- Mechanism of action