This brief video explains DiGeorge syndrome that occurs due to chromosomal deletion, the gene involved, structures affected and presenting distinct facial features. Timeline: 0:00 - Brief introduction of DiGeorge syndrome 1:02 - Distinct facial features of DiGeorge syndrome 1:35 - Cause of DiGeorge syndrome 2:46 - Heart, thyroid and parathyroid gland problems 3:10 - Cleft palate 3:52 - Thymus problems and immunodeficiency