Introduction to Cholesterol synthesis

Cholesterol is a structural component of cell membranes and serves as a building block for synthesizing various steroid hormones, vitamin D, and bile acids. Besides their structural role providing stability and fluidity, cholesterol also plays a crucial role in regulating cell function. The video explains the synthesis of cholesterol with all the steps and enzymes involved. TIMELINE: 0:00 Introduction 2:24 Biosynthesis of cholesterol 3:44 Steps of biosynthesis of cholesterol 5:09 Synthesis of HMG CoA 6:38 Reduction of HMG CoA to Mevalonate 8:19 Formation of Isoprenoid units 8:54 Formation of Squalene 10:21 Formation of Lanosterol 10:44 Formation of cholesterol 10:55 Important events during changing of lanosterol to cholesterol 12:20 Energy cost of Cholesterol Synthesis 12:50 regulation of De novo synthesis of cholesterol 13:46 Sterol dependent regulation of gene expression 16:58 Sterol accelerated enzyme degradation 17:40 Sterol independent covalent modification and hormonal regulation 19:11 Clinical significance of cholesterol 19:24 Clinical conditions associated with high cholesterol levels