High intracranial pressure causes papilledema. Related issues may include: High blood pressure (malignant hypertension). Tumors. Infection, bleeding or inflammation in the brain or the meninges (the tissues that protect the brain and spinal cord). Cerebral venous sinus thrombosis. This condition refers to a blood clot in a vein in your brain. Iron-deficiency anemia. Medication usage. There have been links with retin-A and retinoids, toxic amounts of vitamin A, tetracycline antibiotics, COVID-19 and corticosteroids. Idiopathic intracranial hypertension (IIH). This condition literally means that the patient develops intracranial hypertension without a clear reason or identifiable cause. The word “idiopathic” means that there’s no clear reason or cause.