Products & Services Mayo Clinic Healthy Living Program Symptoms Generalized anxiety disorder symptoms can vary. They may include: Persistent worrying or anxiety about a number of areas that are out of proportion to the impact of the events Overthinking plans and solutions to all possible worst-case outcomes Perceiving situations and events as threatening, even when they aren't Difficulty handling uncertainty Indecisiveness and fear of making the wrong decision Inability to set aside or let go of a worry Inability to relax, feeling restless, and feeling keyed up or on edge Difficulty concentrating, or the feeling that your mind "goes blank"