Hashimoto's disease progresses slowly over the years. You may not notice signs or symptoms of the disease. Eventually, the decline in thyroid hormone production can result in any of the following: Fatigue and sluggishness Increased sensitivity to cold Increased sleepiness Dry skin Constipation Muscle weakness Muscle aches, tenderness and stiffness Joint pain and stiffness Irregular or excessive menstrual bleeding Depression Problems with memory or concentration Swelling of the thyroid (goiter) A puffy face Brittle nails Hair loss Enlargement of the tongue