Paget’s disease is usually a sign of breast cancer in tissue behind the nipple, or breast tissue away from the nipple. The breast cancer can either be: invasive – where cancerous cells invade the surrounding breast tissue non-invasive – where the cancerous cells are contained in one or more areas of the breast and are unable to spread In a small amount of cases, the only evidence of Paget's disease is the nipple changes. In about half of all cases of Paget’s disease of the nipple, a lump is found in the breast. The majority of people with a lump will have invasive breast cancer, although this does not necessarily mean it has spread. Most people with Paget's disease of the nipple who don't have a lump will have non-invasive breast cancer.