Sucralose, a widely used artificial sweetener sold under the trade name Splenda, is metabolized in the gut, producing at least two fat-soluble compounds, according to a recent study using rats. The finding differs from the studies used to garner regulatory approval for sucralose, which reported that the substance was not broken down in the body. The new study also found that sucralose itself was found in fatty tissues of the body.
Source: https://medicalxpress.com/news/2018-08-sucralose-previously-unidentified-metabolites.html