Sheeza Basharatover 2 years ago

Colonoscopy⁠

From celebrities advocating for colonoscopies by sharing their own to new findings about just how much the procedure affects colorectal cancer risk and mortality, various news about the screening method resulted in this week's top trending clinical topic. ⁠ ⁠ At United European Gastroenterology Week 2022, researchers presented findings from a 10-year follow-up of the large, multicenter, randomized NordICC trial. Results showed that a single screening colonoscopy was beneficial, but perhaps not as much as expected.⁠ ⁠ The interim 10-year CRC risk was found to be 0.98% in the invited group, compared with 1.20% in the usual care group (risk ratio, 0.82; 95% CI, 0.70-0.93). This suggests that 455 individuals would need to be invited to undergo colonoscopy to prevent one case of CRC (95% CI, 270-1429). The risk for death from colorectal cancer was 0.28% in the invited group and 0.31% in the usual care group (risk ratio, 0.90; 95% CI, 0.64-1.16).⁠ ⁠ Experts have pointed to several concerns about the study, including the fact that only 42% of those invited actually underwent colonoscopy. ⁠ ⁠ An editorial that accompanied publication of the study points out that cohort studies have found a 40%-69% decrease in the incidence of CRC and a 29%-88% decrease in mortality risk. ⁠