Dementia with Lewy bodies is caused by deposits of an abnormal protein called Lewy bodies inside brain cells. These deposits, which are also found in people with Parkinson’s disease, build up in areas of the brain responsible for things such as memory and muscle movement. It's not clear why the deposits develop and how exactly they damage the brain, but it's thought they disrupt the brain's normal functions by interfering with chemical signals transmitted from one brain cell to another. Dementia with Lewy bodies usually occurs in people with no family history of the condition, although there have been reports of rare cases that seem to run in families.