In most cases, there are no signs of bile duct cancer until it reaches the later stages, when symptoms can include: jaundice – yellowing of the skin and the whites of the eyes, itchy skin, pale stools and dark-coloured urine unintentional weight loss abdominal pain Speak to your GP if you have signs of jaundice or are worried about other symptoms. While it is unlikely you have bile duct cancer, it is best to get it checked.