The Circle of Willis is the joining area of several arteries at the bottom (inferior) side of the brain. At the Circle of Willis, the internal carotid arteries branch into smaller arteries that supply oxygenated blood to over 80% of the cerebrum. Although significant anatomic variations exist, the circle of Willis is typically composed of three cerebral and two communicating arteries that link the internal carotid arteries and the vertebrobasilar system. The internal carotid arteries supply most of the forebrain.