The skin is the body’s largest organ, made of water, protein, fats and minerals. Your skin protects your body from germs and regulates body temperature. Nerves in the skin help you feel sensations like hot and cold. Your skin, along with your hair, nails, oil glands and sweat glands, is part of the integumentary (in-TEG-you-MEINT-a-ree) system. “Integumentary” means a body’s outer covering. Three layers of tissue make up the skin: Epidermis, the top layer. Dermis, the middle layer. Hypodermis, the bottom or fatty layer.