Brushfield spots are ophthalmic findings in individuals with Down syndrome. Brushfield spots are white or greyish spots in the eyes which are present on periphery of the iris. They occur as a result of aggregation of connective tissue. Reference: https://en.wikipedia.org/wiki/Brushfield_spots#:~:text=Brushfield%20spots%20are%20small%2C%20white,in%20his%201924%20M.D.%20thesis. Image via: https://en.wikipedia.org/wiki/Brushfield_spots#:~:text=Brushfield%20spots%20are%20small%2C%20white,in%20his%201924%20M.D.%20thesis.