Methotrexate is a chemotherapeutic agent. It is an immunosuppressant drug used in treatment and management of various cancer and chronic diseases. Though effective, this drug has many adverse effects. These are listed as below: - bone marrow suppression - recurrent infections - shortness of breath - bruising or bleeding - fatigue - liver damage - lung disease - aphthous ulcers - diarrhea - black or bloody stools - blisters - skin peeling - increased risk of lymphoma Reference: https://medlineplus.gov/druginfo/meds/a682019.html Image via: https://www.medicalnewstoday.com/articles/325549