Triggers of Asthma The cause of asthma is a combination of environmental and genetic, both. However, there are triggers different for every individual which cause asthma attack or asthma flare up. • Pollen • Pets • Dust • Insects and insect waste • Cold air • Common cold • Physical activity • Stress • Gastroesophageal Reflux Disease (GERD) • Some medicines e.g. NSAIDs, aspirin, beta-blockers, and ibuprofen