Platelets are prophylactically transfused in neonates in the following conditions: - when platelet count is < 20 x 10 ^ 3 / uL Always transfuse - when platelet count is 20 to < 30 x 10 ^ 3 / uL Transfuse platelets in the following conditions: 1. active bleeding 2. lumbar puncture - when platelet count is 30 to 50 x 10 ^ 3 / uL Transfuse platelets in the following conditions: 1. birth weight < 1 kg 2. intraventricular cerebral hemorrhage 3. coagulation disorder 4. sepsis 5. fluctuating arterial and venous pressure 6. intraparenchymal cerebral hemorrhage 7. alloimmune neonatal thrombocytopenia 8. invasive procedure Reference: https://www.aafp.org/afp/2011/0315/p719.html Image via: https://www.physiciansweekly.com/the-burden-of-platelet-transfusions-in-patients-with-chronic-liver-disease/