While individuals with beta thalassemia trait have no physical findings at all, the beta thalassemia major patients have characteristic physical features. These features are attributed to extramedullary hematopoiesis, iron overload, and ineffective erythropoiesis. These physical features are: - anemia - jaundice - maxillary enlargement - increased spaces between teeth - overbite - malocclusion - dry mouth - tooth decay - hepatomegaly - splenomegaly Reference: https://www.medscape.com/answers/206490-184796/which-physical-findings-are-characteristic-of-beta-thalassemia Image via: https://askhematologist.com/thalassemias/ -