Tissue plasminogen activator is indicated in ischemic stroke. However, there are few absolute contraindications of tPA therapy in stroke patients. These contraindications are: - Intracranial hemorrhage - Suspicion of subarachnoid hemorrhage - Head trauma or any neurosurgery in past 3 months - Uncontrolled hypertension - Arteriovenous malformations - Active bleeding - Endocarditis - History of intracranial hemorrhage Reference: https://www.mdcalc.com/tpa-contraindications-ischemic-stroke Image via: https://www.ahajournals.org/doi/full/10.1161/str.0000000000000152