Wilson disease
Wilson disease is a genetic condition caused because of mutation in the ATP7B protein which transports the copper into the bile for excretion in normal condition. I’m cases of mutation, the copper is not transported for excretion and this results in excessive accumulation of copper in the liver. Such person presents with features of fatigue, loss of appetite, ascites, portal hypertension and neuropsychiatric problems like Parkinsonism, bradykinesia and tremors. Slit lamp examination reveals Kayser-Fleischer rings (brown coloured ring at the corner of iris) as seen in the picture. Picture credit: https://m.youtube.com/watch?v=ETeI3oAjsPg
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