GLUCAGONOMA Glucagonoma is a very rare tumor of the islet cells of the pancreas, which release the hormones insulin and glucagon. Causes Glucagonoma is usually cancerous (malignant). The cancer tends to spread and get worse. This cancer affects the islet cells of the pancreas. As a result, they produce too much of the hormone glucagon. The cause is unknown, but genetic factors play a role in some cases. A family history of multiple endocrine neoplasia type I (MEN I) is a risk factor. Symptoms Diarrhea Excess thirst Frequent urination Increased appetite Inflamed mouth and tongue Nighttime (nocturnal) urination Skin rash on face, abdomen, buttocks, or lower extremities that comes and goes, and moves around May be crusty or scaly May be raised sores (lesions) filled with clear fluid or pus Unintentional weight loss Exams and Tests Signs include: Glucose intolerance High blood sugar (hyperglycemia) Most of the time the cancer has already spread to the liver when it is diagnosed. Tests may include: CT scan Fasting glucose level Glucose tolerance test Serum glucagon Possible Complications The cancer can spread to the liver.
