Orlistat is the only approved drug for treatment of obesity. It is the inhibitor of intestinal lipase. Though effective in reducing weight, the drug is associated with a number of adverse effects. Most common among them are: - Steatorrhea - Abdominal pain and discomfort - Fecal spotting - Diarrhea - Cholestatic hepatitis - Cholelithiasis - Liver failure - Acute kidney injury Reference: https://pubmed.ncbi.nlm.nih.gov/18095746/ Image via: https://www.britannica.com/science/obesity