MEDizzy
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Dr.Sangavi
Dr.Sangavialmost 8 years ago

How hexokinase deficiency cause hemolytic anaemia???

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almost 8 years ago

Nonspherocytic hemolytic anemia due to hexokinase deficiency has been shown to be caused by mutations in the HK1 gene, which cause at least a partial deficiency of the enzyme hexokinase.[1][4] This enzyme plays an important role in the chemical processes involved in the breakdown of sugar molecules (glycolysis). Red blood cells depend on this process for energy; if an enzyme is defective in any one of the stages, the red blood cell cannot function properly and hemolysis takes place.[6] When red blood cells cannot be replaced faster than they destroy themselves, anemia results.

almost 8 years ago

Thank you so much

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