Role of Serology in Diagnosis of Adenovirus Infection Serology is an important laboratory test for the diagnosis of Adenovirus infection. It is actively employed by commercial laboratories and hospitals. It aids in diagnosing Adenovirus especially in children. Most of the children demonstrate positive Adenovirus titers by the age of 4 years. The titers increase 4 times in the second follow-up test which is usually after 2-4 weeks. It is important to conduct this test in the initial phase of clinical course.