Primary Biliary Cholangitis

Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is a chronic possibly autoimmune disease of the liver. It leads to progressive cholestasis and often end-stage liver disease. Epidemiology: females; between forth and sixth decades of life Symptoms: fatigue, pruritus and right upper-quadrant pain Signs: dry eyes and mouth found in 50%-75%, hepatomegaly, hyperpigmentation, splenomegaly, jaundice The hallmark of PBC is the presence of antimitochondrial antibodies (AMAs) in serum. Management: Ursodeoxycholic acid, antihistamines for pruritis. Text Reference: https://emedicine.medscape.com/article/171117-overview#a1 Image Source: http://www.transplantliverinindia.com/primary-biliary-cholangitis/