Acute Renal Failure with ACE Inhibitors

There can be an acute decline in renal function with initiation of ACE inhibitor therapy or this process can after chronic use specially in the cases of CHF. One of the following mechanisms can be involved behind this affect of ACE inhibitors on the renal function: - ACE inhibitors resulting in MAP decline to an insufficient level for proper renal perfusion or reflexive activation of renal sympathetic system. - ACE inhibitor therapy + Diuretic use in patients with CHF - Predisposing other factors such as high-grade bilateral renal artery stenosis or other vessel related significant pathologies - ACE inhibitor therapy + Vasoconstrictor agents (NSAIDs, cyclosporine) Text Reference and Image Source: https://www.ahajournals.org/doi/10.1161/hc4101.096153