What is the role of Losartan in the treatment of coronavirus disease 2019 (COVID-2019)?
Covid-19 infection increases the angiotensin 2 signalling pathway mediated by AT1 receptors which exacerbates lung injury. Losartan is an AT1 receptor antagonist. It reduces the fatal outcomes of a SARS Cov-2 infection in hospitalized patients by limiting lung damage and other pulmonary complications.
Losartan for COVID-19 Treatment Losartan is an anti-hypertensive drug used for the treatment of hypertension and heart failure. It prevents cardiovascular and renal complications. Hypothesis indicates Losartan as a potential candidate for the treatment of COVID-19. Losartan can inhibit vasoconstriction initiated by angiotensin 2 which is likely to play a significant role in Rennin-Angiotensin-Aldosterone System (RAAS).
