MEDizzy
MEDizzy
D K MEDILIFE
D K MEDILIFEabout 7 years ago

Can tell some potassium sparing diuretics

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about 7 years ago

Aldactone, Inspra, Midamor

about 7 years ago

Potassium-sparing diuretics are diuretic drugs that do not promote the secretion of potassium into the urine. They are used as adjunctive therapy, together with other drugs, in the treatment of hypertension and management of congestive heart failure.

about 7 years ago

Potassium-sparing diuretics are generally used in combination with other diuretic drugs (e.g. loop diuretics) that would otherwise tend to lower the potassium levels to potentially dangerous low levels (hypokalemia). The combination therefore helps maintain a normal reference range for potassium.

about 7 years ago

On their own this group of drugs may raise potassium levels beyond the normal range, termed hyperkalemia, which risks potentially fatal arrhythmias.

about 7 years ago

The potassium-sparing diuretics are competitive antagonists that either compete with aldosterone for intracellular cytoplasmic receptor sites, or directly block sodium channels (specifically epithelial sodium channels (ENaC) by amiloride). The former prevents the production of proteins that are normally synthesized in reaction to aldosterone. These mediator proteins are not produced, and so stimulation of sodium-potassium exchange sites in the collection tubule does not occur. This prevents sodium re-absorption and potassium and hydrogen ion secretion.

about 7 years ago

Those in clinical use include: Epithelial sodium channel blockers Amiloride Triamterene Aldosterone antagonists (mostly spirolactones): Spironolactone Eplerenone

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