CADASIL or cerebral autosomal dominant arteriopathy w/subcortical infarcts & leukoencephalopathy is a rare genetic disorder affecting small vessels in the brain. Its typical features include recurrent strokes, cognitive impairment and psychiatric issues, and migraine with aura. Due to disturbances in the NOTCH signaling pathway, eosinophilic material begins to deposit within small vessels and there is reduction of blood flow to the brain. This culminates in small strokes (or lacunes), small bleeds (microbleeds), and tissue loss in the surface of the brain (cortex) as well underneath the cortex (subcortical region). Source: https://rarediseases.org/rare-diseases/cadasil/