Gilbert Syndrome

Gilbert Syndrome is an autosomal recessive hereditary disorder that arises due to mutation in the UGT1A1 gene (promotor region) causing decreased UGT. This syndrome is characterised by intermittent jaundice without the presence of any kind of evident haemolysis or underlying liver pathology. Decreased activity of UGT results in decreased conjugation of bilirubin and increased serum levels of unconjugated bilirubin that manifests as intermittent jaundice when the body undergoes stressors. Text Reference: https://www.medscape.com/answers/178841-68016/what-is-gilbert-syndrome Image Source: https://bestpractice.bmj.com/topics/en-us/346