Shari

I understand of course how it's gotten but why does it effect the body and the brain so hard when mot treated

Nics 🙂

Thank you, that explaination was very helpful. I really appreciate that you answer me back, thank you again 🙂

Emerald Perez

I'm not sure if I explained it well, but there are researches which will explain more about the association of immune response to Syphilis. Tho they are limited, but it is really the immune response what caused its clinical symptoms

Hi! This is a very interesting question! But yeah, in the case of Syphilis, the main reason for the lesion is the immune response of the infected  host who's in the Tertiary stage of Syphilis. 

For example, our body, whenever there are foreign thing or bacteria (for instance), our immune system will eventually react which in some cases initiate symptoms. Same goes with Treponema pallidum (the causative agent for Syphilis). 

In tertiary stage of Syphilis, the patient develop a type IV hypersensitivity reaction to make a strong immune response against T.paidum  This immune response is led by our immune cells. However,  these immune cells get overexcited and can form gumma (the lessions) . 

These lesions were caused by Treponema pallidum, which is a causative agent of Syphilis. Typically, this is sexually transmitted disease and it is sub divided into 3 stages depending on the severity and the degree of clinical manifestations. The photo attached is a Tertiary Syphilitic Lessions (Final stage) and it is manifested if Syphilis were left untreated for 2-10 years. 


Link: https://www.news.com.au/lifestyle/health/health-problems/the-shocking-photos-of-syphilis-victims-before-penicillin/news-story/d490d2fc9d50e311feeea1f253a135e3

Syphilis

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