Natural killer (NK) cells play a key role in antiviral and tumour immunity. In the setting of HIV infection, accumulating evidence implicates NK cells as critical contributors to immune control of HIV. In particular, indirect NK cell-mediated antibody-dependent cellular cytotoxicity (ADCC) has been linked to vaccine-induced protective immunity against HIV infection and phenotypes of viral control. NK cells recognise stress signals, cancer transformation or infection with immediate effector function achieved via expression of a wide array of receptors and integration of finely attuned signals. In addition to cytotoxic elimination of target cells, NK cells are potent producers of cytokines and chemokines and can promote or suppress adaptive and innate immune responses.
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