Its a genetic condition which effects the bone, soft tissue, skin and nervous system. Clinical manifestation increase over time. Its has two distinct types, NF1 and NF2. NF1 presents with flat brown birthmarks, freckling in skin folds and multiple tumours that hang off the skin. NF2 occurs 1 in 50,000 births. Its also known as bilateral acoustic neurofibromatosis. It is characterized by multiple lesions on brain and spinal cord. It occurs due to gene mutation on chromosome 17 and 22 respectively. There is no known cure of NF. Lesions or tumours that become large and painful can be cut out surgically to reduce the risk of malignancy.