Albright’s Hereditary Osteodystrophy
The resistance to many hormones, particularly parathyroid hormone, manifests as Albright’s Hereditary Osteodystrophy, also known as pseudohypoparathyroidism type 1a. It is an autosomal dominant disease that occurs due to mutation of GNAS gene. The signs and symptoms of Albright’s Hereditary Osteodystrophy are: - Obesity - Round face - Short stature - Bone formation in subcutaneous tissue - Brachydactyly The treatment of Albright’s Hereditary Osteodystrophy includes supplementary vitamin D and calcium. Low phosphorus diet is also indicated in case of elevated phosphate levels. Reference: https://rarediseases.info.nih.gov/diseases/5770/albrights-hereditary-osteodystrophy Image via: https://www.researchgate.net/publication/221920511_Pseudohypoparathyroidism_in_Children/figures?lo=1&utm_source=google&utm_medium=organic
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