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Veer Tamangabout 4 years ago
What is the reason for checking TPMT levels in ulcerative colitis?
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about 4 years ago
To assess the patient's risk of serious side effects from treatment with thiopurines (e.g. azathioprine, mercaptopurine and thioguanine).
When a patient presents with an acute episode of ulcerative colitis. Management includes symptomatic relief of pain, anti-inflammatory and IV steroid therapy. Apart from these immunosuppressant use is also recommended. The commonly used are thiopurines. These include: azathioprine and metcaptopurines. These drugs when given are monitored. Thiopurines are metabolized by thiopurine methyl transferase enzymes, in absence of this enzymes giving these drugs can be fatal. Hence TPMT levels are checked before starting a treatment with thiopurines.
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Ulcerative colitis is a long-term condition where Symptoms of ulcerative colitis
The main symptoms of ulcerative colitis are:
recurring diarrhoea, which may contain blood, mucus or pus
tummy pain
needing to empty your bowels frequently
You may also experience extreme tiredness (fatigue), loss of appetite and weight loss.
The severity of the symptoms varies, depending on how much of the rectum and colon is inflamed and how severe the inflammation is.
For some people, the condition has a significant impact on their everyday lives.
Symptoms of a flare-up
Some people may go for weeks or months with very mild symptoms, or none at all (remission), followed by periods where the symptoms are particularly troublesome (flare-ups or relapses).
During a flare-up, some people with ulcerative colitis also experience symptoms elsewhere in their body.
For example, some people develop:
painful and swollen joints (arthritis)
mouth ulcers
areas of painful, red and swollen skin
irritated and red eyes
In severe cases, defined as having to empty your bowels 6 or more times a day, additional symptoms may include:
shortness of breath
a fast or irregular heartbeat
a high temperature (fever)
blood in your stools becoming more obvious
In most people, no specific trigger for flare-ups is identified, although a gut infection can occasionally be the cause.
Stress is also thought to be a potential facto the colon and rectum become inflamed.Lead Pipe Appearance of ColonIdentify the Radiographical FindingInflammatory bowel diseaseCrohns disease vs ulcerative colitisFDA Approves Mirikizumab for Ulcerative ColitisUlcerative Colitis vs Crohn DiseaseTruelove and Witts Criteria for Ulcerative ColitisCrohn's Vs UCCrohn's Vs Ulcerative Colitis
