It is complication of long standing reflux disease. After several years of GERD, normal epithelial lining changes from squamous to columnar epithelium. Men age more than 50 with chronic GERD (+5 years) with additional risk factors (nocturnal symptoms, hiatal hernia, smokers) should be screened. Patient with Barrett esophagus should have repeated endoscopy every 3-5 years to check for dysplasia or cancers. - If low grade dysplasi, repeat endoscopy 6-12 months. - If high grade, do radiofraquency ablation or endoscopic mucosal resection. - The usual rate of progression to cancer 0.5% every year. All patients with Barrett esophagus should receive PPIs.