# Pathophysiology Obesity
Several organs are affected by genes associated with predisposition to obesity. The CNS is the main regulator of energy expenditure and feeding behaviour, and mutations in genes in this region result in increase in bodyweight. In the digestive tract, mutations in taste receptor genes and digestive enzymes in the mouth correlate to higher BMI as well. Furthermore, mutations in genes involved in digestion of lactose in the stomach, disruption of gut microbiota equilibrium, lipid and glucose metabolism could result in obesity. The genes involved in the musculoskeletal system's growth and glucose transport are associated with obesity. Genes involved in fat distribution and adipogenesis can result in obesity through a cascade of events that affect the body's energy homoeostasis. WAT, white adipose tissue .