Parkinson’s disease is a neurodegenerative disorder characterised by loss of dopaminergic neurons in the substantia nigra. The patient presents with mask like face, shuffling gait, rigidity, resting tremors, bradykinesia and instability. The picture shows loss of pigmentation in the substantia nigra in Parkinson’s disease patient compared to the normal one. Picture credits: https://neuropathology-web.org/chapter9/chapter9dPD.html