Nitric Oxide for COVID-19 Treatment Nitric Oxide exists as a free radical. Free radicals are known for their aggressive and degenerating reactions in body. It has important role in immune system and cardiovascular system. Its participation indicates immune inflammation and vascular dysfunction in COVID-19 patients. Society of Critical Care Medicine does not recommend iNO therapy for COVID-19 patients. However, the society suggests iNO therapy in patients with hypoxemia and ARDS. All such candidates must be mechanically ventilated. Cost of iNO therapy = $100/hour