Edema is a common presentation of liver cirrhosis. In this condition, hepatocytes stop producing or produce very minor quantity of a very important protein called albumin. The concentration of albumin is diluted by sodium and water retention which is another common occurrence in liver cirrhosis. The extent of edema is dependent upon the concentration of albumin. When albumin is lost and sodium and water retention occurs, fluid begins to collect in the extracellular spaces of body causing swelling or edema.

Because when occurred liver damage, the one impact is production protein, such as albumin, globulin. When the liver has damage, the production of this protein will decrease. As well as protein has function to keep osmolaritas pressure in vasculer, when protein is decreased, osmolarity of presur in vasculer will less compared in interstitial, So, it will make water in vasculer will move to interstitial and make manifestation like edema

Liver produces plasma proteins like albumin and globulin that maintain the interstitial pressure. In liver diseases,the functions of liver are compromised thus lack of production of plasma protein results in edema. Same goes with nephrotic syndrome in which plasma proteins are lost.