Mid-foot amputation due to diabetic gangrene!! Gangrene can develop when the supply of blood to an area of your body is interrupted. This can occur as the result of an infection arising from an injury, and/or due to hardening and narrowing of the arterial walls both resulting in obstruction of blood supply. All of your organs need oxygen to survive. If one of your body parts isn’t getting oxygen through your blood, it can deteriorate and die. People with diabetes have an increased risk of developing gangrene. This is because the high blood sugar levels associated with the condition damages the nerves, particularly those in the feet, which can make it easy to injure yourself without realising. High blood sugar can also damage your blood vessels, restricting the blood supply to your feet. Less blood means your feet will also receive fewer infection-fighting cells, so wounds will take longer to heal and are more likely to become infected. An infection can spread quickly and, if left untreated, can lead to sepsis and eventually death.