How you will differentiates dyplasia ,cancer in situ, malignant cancer???😉
Cancer in Situ has no basement membrane penetration, also dysplasia stays within basement membrane. Malignant cancer has already crossed the basement membrane by using substances such as metalloproteases and many more which help the cancer to cross tissues and membranes.
By cell morphology changes, growth pattern, number of mitosis, cytoplasm to nucleus ratio, if basement membrane is penetrated or not.
Can you tell me more clearly about basement membrane in all three conditions?
It resembles to a cheesecake... cancer in situ is just like damaging the sweet cover, dysplasia is getting all the content of it and malignant cancer is when it crosses the crust (basal membrane)
