Amazing article. Amazing theory. Hope it's proven. I think it'd help a lot in the fight against the covid-19.

Juliana Paixão

Dr Andrew Wilner speaks with the researcher proposing that the renin-angiotensin system is the reason for COVID-19's complex symptoms.

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Dustin

Could RAS Dysfunction Explain COVID's Effects?

The RAS has two basic "arms" of action that counterbalance each other. The ACE/angiotensin II/AT1 receptor axis promotes coagulation, inflammation, fibrosis, and insulin resistance. The ACE2/angiotensin1-7/Mas receptor/AT2 receptor axis does largely the opposite: anti-inflammatory, anticoagulant, and so on. Both original SARS and SARS-CoV-2 use “ACE2 to hitchhike inside cells, then they highjack cellular machinery for viral replication and halt cellular expression of ACE2. Without the ACE2 counterbalance, the destructive potential of unchecked ACE/angiotensin II/AT1 is unleashed”  an interesting perspective

Could RAS Dysfunction Explain COVID's Effects?

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