Neurofibromatosis(Von Recklingausen ́s disease) is a multisystem genetic disease of autosomal dominant transmission known as Von Recklingausen ́s disease, characterized by the presence of typical skin lesions such as light brown spots and neurofibromas that are benign tumors of peripheral nerves. We present here, a case of a 32-year-old woman who presents headache and respiratory distress finding in the physical examination multiple neurofibromas and light brown spots through the body and hamartomatous lesions in the iris. @jpabloandradej