The kidneys primary job is to perform water reabsorption, regulate ionic concentrations, maintain body pH and filter/excrete harmful byproducts of protein metabolism, such as urea. Over time kidneys ability to filter blood decreases, which is measured by a value termed as the Glomerular Filtration Rate. Significant decline in GFR suggest that the filtering ability of the kidney is lost and harmful products can build up, which can cause multi-system organ dysfunction. •> The term “chronic kidney disease” means lasting damage to the kidneys that can get worse over time. If the damage is severe, the kidneys may stop working. This is called kidney failure, or end-stage renal disease (ESRD). Chronic kidney disease (CKD) can result from the following known factors: -Hypertension -Diabetes mellitus -Heart diseases -Increased age.