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about 7 years ago
Unripen fruit of achee has the hypoglycemia A that binfs irreversibly with CoA, Creatinine, creatinine acyl transferase I,II inhibiting the Beta oxidation of fatty acids
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about 7 years ago
Hypoglycin A, which is now simply called hypoglycin, is metabolized by means of transamination and oxidative decarboxylation to methylene cyclopropyl acetic acid (MCPA). MCPA forms nonmetabolizable carnitine and coenzyme A (CoA) esters, thereby depressing tissue levels of these cofactors and making them less available for other biochemical reactions. Hypoglycemia results because both CoA and carnitine are necessary cofactors for long-chain fatty acid oxidation and because oxidation is a requisite for active gluconeogenesis
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