Direct Thrombin Inhibitors and Factor Xa Inhibitors | Pharmacology | Hematology
Warfarin (anticoaulant) | Hematology & Pharmacology. Warfarin is an anticoagulant that inhibits the epoxide reductase enzyme which prevents the activation of vitamin K. Therefore, Warfarin inhibits the gamma carboxylation (gamma-glutamyl carboxylase) of the coagulation factors II, VII, IX, IX (2,7,9,10) as well as Protein C, Protein S, and Protein Z. Heparin is an anticoagulant that stimulates antithrombin III (ATIII) which then inhibits coagulation factors VII, IX, X, XI, XII, as well as thrombin. This leads to prevention of thrombus formation (anticoagulation)...Heparin is used for ICU anticoagulation...Adverse effects of heparin includes bleeding, Heparin-induced thrombocytopenia (HIT), and osteoporosis. Anticoaulants are chemicals that inhibit blood coagulation (secondary hemostasis).