The price erythrocytes pay for their abundant content of hemoglobin to the exclusion of the usual specialized intracellular machinery is shortened life span.
Perché è un tipo di cellula super specializzata, andando incontro al differenziamento perde il nucleo per lasciare quanto più spazio possibile all’emoglibina per trasportare ossigeno ai tessuti. Senza nucleo non può codificare le informazioni che codificano per la sintesi di nuove proteine. In circa 120 giorni vanno incontro ad una degenerazione tale da rendersi necessaria la loro eliminazione, che viene sostituita continuamente dal l’immissione di nuove cellule eritrocitarie.
Without DNA and RNA, erythrocytes cannot synthesize proteins for cellular repair, growth, and division or for renewal of enzyme supplies. Equipped only with initial supplies synthesized before extrusion of their nucleus, or organelles, and ribosomes, erythrocytes survive an average of 120 days, in contrast to nerve and muscle cells, which last a person’s entire life.
As an erythrocyte ages, its nonreparable plasma membrane becomes fragile and prone to rupture as the cell squeezes through tight spots in the vascular system.
I'm having a problem understanding brother. This question ask me in viva of physiology and i can't satisfied to examiner??😢😢
RBC don't have any Nucleus (Dna) to syn. New proteins. It gets few proteins before it looses the nucleus during erythroblast stage. But proteins don't stay forever right. So when they get exhausted the cell dies. It is believed the proteins get exhausted in 120 days.
